翻訳と辞書 Words near each other ・ SLC7A11 ・ SLC7A14 ・ SLC12A9 ・ SLC13A2 ・ SLC13A3 ・ SLC13A5 ・ SLC14A1 ・ SLC14A2 ・ SLC15A2 ・ SLC15A4 ・ SLC16A5 ・ SLC17A1 ・ SLC17A3 ・ SLC17A5 ・ SLC17A8 ・ SLC19A1 ・ SLC19A2 ・ SLC19A3 ・ SLC1A1 ・ SLC1A2 ・ SLC1A4 ・ SLC1A5 ・ SLC20A1 ・ SLC20A2 ・ SLC22A1 ・ SLC22A10 ・ SLC22A11 ・ SLC22A12 ・ SLC22A18 ・ SLC22A2 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク SLC19A1 ： ウィキペディア英語版 SLC19A1 Solute carrier family 19 (folate transporter), member 1, also known as SLC19A1 or RFC1, is a protein which in humans is encoded by the ''SLC19A1'' gene. == Function == Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6573 )〕 == Clinical significance == Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate. Other studies have also shown that individuals carrying the c.80AA polymrophism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SLC19A1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.