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Glutamate aspartate transporter
Solute carrier family 1 (glial high-affinity glutamate transporter), member 3, also known as SLC1A3,is a protein that, in humans, is encoded by the ''SLC1A3'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6507 )〕 SLC1A3 is also often called the GLutamate ASpartate Transporter (GLAST) or Excitatory Amino Acid Transporter 1 (EAAT1) .
GLAST is predominantly expressed in the plasma membrane, allowing it to remove glutamate from the extracellular space. It has also been localized in the inner mitochondrial membrane as part of the malate-aspartate shuttle.
== Mechanism ==
GLAST functions ''in vivo'' as a homotrimer. GLAST mediates the transport of glutamic and aspartic acid with the cotransport of three Na+ and one H+ cations and counter transport of one K+ cation. This co-transport coupling (or symport) allows the transport of glutamate into cells against a concentration gradient.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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