|
Sodium/potassium/calcium exchanger 5 (NCKX5), also known as solute carrier family 24 member 5 (SLC24A5), is a protein that in humans is encoded by the ''SLC24A5'' gene that has a major influence on natural skin colour variation. The NCKX5 protein is a member of the potassium-dependent sodium/calcium exchanger family. Sequence variation in the ''SLC24A5'' gene, particularly a non-synonymous SNP changing the amino acid at position 111 in NCKX5 from alanine to threonine, has been associated with differences in skin pigmentation. The SLC24A5 gene's derived threonine or ''Ala111Thr'' allele (rs1426654〔(Reference SNP(refSNP) Cluster Report: rs1426654 * *clinically associated * * ). Ncbi.nlm.nih.gov (2008-12-30). Retrieved on 2011-02-27.〕) has been shown to be a major factor in the light skin tone of Europeans compared to Africans, and is believed to represent as much as 25–40% of the average skin tone difference between Europeans and West Africans.〔 It has been the subject of recent selection in Western Eurasia, and is fixed in European populations. == Gene == The ''SLC24A5'' gene, in humans, is located on the long (q) arm of chromosome 15 on position 21.1, from base pair 46,200,461 to base pair 46,221,881.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SLC24A5」の詳細全文を読む スポンサード リンク
|