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・ Sleaford Mere Conservation Park
・ Sleaford Mods
・ Sleaford Navigation
・ Sleaford railway station
・ Sleaford Rural District
・ Sleaford Town F.C.
・ Sleaford Town Runners
・ Sleaford, Hampshire
・ Sleagill
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・ Sleat
・ SLC25A27
・ SLC25A29
・ SLC25A3
SLC25A31
・ SLC25A38
・ SLC25A39
・ SLC25A4
・ SLC25A5
・ SLC25A6
・ SLC26A2
・ SLC26A3
・ SLC26A6
・ SLC26A7
・ SLC26A8
・ SLC27A1
・ SLC27A2
・ SLC27A3
・ SLC27A4


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SLC25A31 : ウィキペディア英語版
SLC25A31

ADP/ATP translocase 4 (ANT4) is an enzyme that in humans is encoded by the ''SLC25A31'' gene on chromosome 4.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83447 )〕 This enzyme inhibits apoptosis by catalyzing ADP/ATP exchange across the mitochondrial membranes and regulating membrane potential.〔 In particular, ANT4 is essential to spermatogenesis, as it imports ATP into sperm mitochondria to support their development and survival.〔 Outside of this role, the ''SLC25AC31'' gene has not been implicated in any human disease.
== Structure ==

The ANT4 protein contains six transmembrane helices, and a homodimer functional unit, which serves as an ADP/ATP channel protein.〔 Unlike the other three ANT isoforms, ANT4 has additional amino acids at its N- and C-terminals. These amino acid sequences may interact with different factors for specialized functions such as localization to sperm flagella.〔〔 The ''SLC25A31'' gene is composed of 6 exons over a stretch of 44 kbp of DNA.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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