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SLC25A5
Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 is a protein that in humans is encoded by the SLC25A5 gene on the X chromosome.〔
(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/gene/292 )〕
This protein functions as an antiporter for ADP/ATP exchange between the mitochondrial matrix and cytoplasm. 〔 As a result, it plays a key role in maintaining mitochondrial membrane potential and inhibiting apoptosis and has been targeted for treating cancer.〔〔
== Structure ==
The ''SLC25A5'' gene belongs to the ANT gene family, which itself belongs to the superfamily that includes genes encoding brown fat mitochondrial uncoupling proteins and mitochondrial phosphate carrier proteins. Compared to the other gene isoforms, ''SLC25A5'' possesses different motifs, including a CCACT sequence rather than the canonical CCAAT sequence upstream of the TATA box, as well as five SP1 binding sites. This gene consists of 4 exons, while its encoded protein forms a homodimer embedded in the inner mitochondrial membrane.〔〔 The entire protein is composed of 300-320 amino acid residues folded into six transmembrane helices. The human genome contains four differentially expressed isoforms, as well as several non-transcribed pseudogenes, of this gene.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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