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4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the ''SLC3A2'' (solute carrier family 3 member 2) gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6520 )〕 SLC3A2 comprises the light subunit of the large neutral amino acid transporter (LAT1) that is also known as CD98 (cluster of differentiation 98). == Function == SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.〔 LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.〔 A functional LAT1 transporter is composed of two proteins encoded by two distinct genes: * 4F2hc/CD98 heavy subunit protein encoded by the SLC3A2 gene (this gene) * CD98 light subunit protein encoded by the SLC7A5 gene 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SLC3A2」の詳細全文を読む スポンサード リンク
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