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STARR-seq
STARR-seq (also known as self-transcribing active regulatory region sequencing) is a novel method to assay enhancer activity for millions of candidates from arbitrary sources of DNA. Being a highly reproducible technique, STARR-seq identifies the sequences that act as transcriptional enhancers in a direct, quantitative, and genome-wide manner.
==Introduction==
In eukaryotes, transcription is regulated by sequence-specific DNA-binding proteins (transcription factors) associated with a gene’s promoter and also by distant control sequences including enhancers. Enhancers are non-coding DNA sequences, containing several binding sites for a variety of transcription factors. They typically recruit transcriptional factors that modulate chromatin structure and directly interact with the transcription machinery placed at the promoter of gene. Enhancers are able to regulate transcription of target genes in a cell type-specific manner,〔 independent of their location or distance from the promoter of genes. Occasionally, they can regulate transcription of genes located in a different chromosome.
However, the knowledge about enhancers so far has been limited to studies of a small number of enhancers, as they have been difficult to identify accurately at a genome-wide scale.〔 Moreover, many regulatory elements function only in certain cell types and specific conditions.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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