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STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes). Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic. == Interactions == STAT1 has been shown to interact with: * BRCA1, * C-jun, * CD117, * CREB-binding protein, * Calcitriol receptor, * Epidermal growth factor receptor,〔〔 * Fanconi anemia, complementation group C, * GNB2L1,〔 * IFNAR2, * IRF1, * ISGF3G * Interleukin 27 receptor, alpha subunit, * MCM5, * Mammalian target of rapamycin, * PIAS1, * PRKCD,〔 * PTK2, * Protein kinase R, * STAT2, * STAT3, * Src, and * TRADD. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「STAT1」の詳細全文を読む スポンサード リンク
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