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STX10
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・ STXBP1
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STX10 : ウィキペディア英語版
STX10

Syntaxin-10 (STX10) is a SNARE protein that is encoded by the ''STX10'' gene. This protein is found in most vertebrates (including humans) but is noticeably absent from mice. As with other SNARE proteins, STX10 facilitates vesicle fusion and thus is important for intracellular trafficking of proteins and other cellular components. More specifically, STX10 has been implicated in endosome to Golgi trafficking of the mannose 6-phosphate receptor〔 and glucose transporter type 4.〔
STX10 has been detected in the trans-Golgi network (TGN) by immunofluorescence.〔
== Structure and function ==

Human STX10 is a 249 amino acid protein that has three N-terminal α-helices and a single SNARE domain followed by a single-pass transmembrane domain. Human STX10 is 60% identical to human STX6.〔
STX10 is structurally classified as a Qc-SNARE (contributes a glutamine (Q) residue in the formation of the assembled core SNARE complex) and is functionally classified as a t-SNARE (or target-SNARE which is often located in the membranes of target compartments).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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