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SX-3228
SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.
SX-3228 is a subtype-selective GABAA positive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies.〔Sanger DJ. The effects of new hypnotic drugs in rats trained to discriminate ethanol. ''Behavioural Pharmacology''. 1997 Aug;8(4):287-92.〕〔Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ. Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands. ''Behavioural Pharmacology''. 1999 Sep;10(5):483-95.〕 It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation.〔Griebel G, Perrault G, Sanger DJ. Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents. ''Journal of Psychopharmacology''. 1998;12(4):356-65.〕〔Alvariño F, Monti JM, Jantos H, Monti D. Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat. ''Brazilian Journal of Medical and Biological Research''. 1999 Aug;32(8):1007-14.〕
== References ==
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