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Sacubitril
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Sacubitril : ウィキペディア英語版
Sacubitril

Sacubitril (INN; developmental code name AHU-377) is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as ''LCZ696'' and marketed under the brand name, ''Entresto'', is a treatment for heart failure.〔 It was approved under the FDA's priority review process for use in heart failure on July 7, 2015.
==Mechanism of action==
Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases.〔 Sacubitrilat inhibits the enzyme neprilysin,〔 which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure-lowering peptides that work mainly by reducing blood volume.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Sacubitril」の詳細全文を読む



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