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・ Sarala Das
・ Sarala Devi Chaudhurani
・ Sarala Kariyawasam
・ Sarala Regmi
・ Sarala Roy
・ Sarala Temple
・ Saralan
・ Saraland City Schools
・ Saraland High School
・ Saraland, Alabama
・ Saralanj
・ Saralanj, Aragatsotn
・ Saralanj, Kotayk
・ Saralanj, Lori
・ Saralanj, Shirak
Saralasin
・ Saralee Thungthongkam
・ Saralegui
・ Saralisa Volm
・ Sarallah
・ Sarallı Xəşbab
・ Saralyn R. Daly
・ Saralyn Smith
・ Saram
・ Saram, Mazandaran
・ Sarama
・ Sarama (Ramayana)
・ Sarama (Thai music)
・ Sarama, Cyprus
・ Saramacca


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Saralasin : ウィキペディア英語版
Saralasin
chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 347942559
| ImageFile=saralasin.png
| ImageSize=200px
| IUPACName=(2''S'')-2-amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1''H''-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
" TITLE="
(2''S'')-2-(2''S'')-2-(2''S'')-2-(2''S'')-5-(diaminomethylideneamino)-2-2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1''H''-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
"> OtherNames=Sar-Arg-Val-Tyr-Val-His-Pro-Ala
of angiotensin II receptors, though it is commonly mistaken as a competitive antagonist. Saralasin's distinction as a partial agonist is based on the fact that its therapeutic effect (i.e. reduced hypertension) is only observed in patients with high plasma angiotensin II levels, but in patients with low angiotensin II levels Saralasin causes hypertension. In other words, the effects of Saralasin on the angiotensin II receptor in the absence of angiotensin II is pharmacodynamically similar to angiotensin II itself thus it is a partial agonist, because if it was an antagonist it would not elicit an effect when bound to its receptor. Saralasin is an angiotensin II analogue, containing sarcosine-1 and ()]-8, hence the name (sarcosine, alanine, angiotensin).
==External links==

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抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Saralasin」の詳細全文を読む



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