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Anti-Scl-70 antibodies
Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome.〔Table 5-9 in: 8th edition.〕 Anti Scl-70 antibodies are associated with more severe scleroderma disease.
The etymology of scl-70 consists of an abbreviation of scleroderma and a 70 kD extractable immunoreactive fragment that can be obtained from the otherwise larger (100–105 kD) target topoisomerase antigen (called the SCL-70 Antigen) of the antibodies.〔(Product Name: SCL-70 Antigen ) at ImmunoVision.com, retrieved April 2011〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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