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Sec61 is an endoplasmic reticulum (ER) membrane protein translocator (aka translocon). It is a doughnut shaped pore through the membrane with 3 major subunits (heterotrimeric). It has a region called the plug that blocks transport into or out of the ER. This plug is displaced when the hydrophobic region of a nascent polypeptide interacts with another region of Sec61 called the seam, allowing translocation of the polypeptide into the ER lumen. ==Human proteins== * SEC61A1 * SEC61A2 * SEC61B * SEC61G 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Sec61」の詳細全文を読む スポンサード リンク
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