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Seipin
Seipin is a homo-oligomeric integral membrane protein in the endoplasmic reticulum (ER) that concentrates at junctions with cytoplasmic lipid droplets (LDs). Alternatively, seipin can be referred to as Bernardinelli-Seip congenital lipodystrophy type 2 protein (BSCL2), and it is encoded by the corresponding gene of the same name, i.e. BSCL2. At protein level, seipin is expressed in cortical neurons in the frontal lobes, as well as motor neurons in the spinal cord. It is highly expressed in areas like the brain, testis and adipose tissue. Seipin's function is still unclear but it has been localized close to lipid droplets, and cells knocked out in seipin which have anomalous droplets. Hence, recent evidence suggests seipin to play a crucial role in lipid droplet biogenesis.
== Function ==
Initially dubbed "mysterious protein", recent empirical studies gradually start to unveil some of seipin's most compelling physiological functions. Among these, the following have been identified: central regulation of energy homeostasis, lipid catabolism (essential for adipocyte differentiation), lipid storage and lipid droplet maintenance, as well as prevention of ectopic lipid droplet formation in non-adipose tissues. Additionally, mutations of BSCL2 have been recently linked to the Silver-Syndrome and Celia's Encephalopathy.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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