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SensiQ Technologies, Inc. is a manufacturer of surface plasmon resonance (SPR) based instruments used to detect biological interactions between proteins, peptides, antibodies, and organic molecules. The most common analysis performed are the determination of binding affinity and kinetic parameters, and to identify binding partners in a qualitative manner1,2. It can also be used to perform concentration assays without amplification or labeling typically used in ELISA and ultraviolet-visible spectroscopy. SensiQ Technologies headquarters is located in Oklahoma City, Oklahoma. The operations of SensiQ Technologies were formerly a division of ICx Nomadics/FLIR Systems, until the operations and product line were acquired by the private equity group TechVen Partners, LLC in May 2012 and subsequently incorporated as independently.5 The SensiQ line of products has been in production since 2007.4 ==Products== SensiQ Pioneer FE is a three-channel automated SPR instrument released June 2014, that is specifically tailored to fragment screening, particularly the detection and characterization of fragment binding events. It utilizes SensiQ Technologies' proprietary dynamic injection SPR (diSPR®) and actives selection software to provide label-free identification and characterization of fragment actives in screening campaigns. SensiQ Pioneer is a three-channel automated SPR instrument with permanent optics. It provides real-time label-free biomolecular interactions analysis, using diSPR®. Suited for applications such as: Fragment Based Lead Discovery, Antibody Characterization, Protein-Small Molecule Interactions, Protein-Protein Interaction Kinetics. SensiQ and SensiQ Discovery are two-channel semi-automated and manually operated instruments, respectively, that use the disposable Spreeta SPR sensor developed by Texas Instruments3 and licensed from Sensata Technologies5. These SPR instruments were developed to utilize the Spreeta sensor technology which ICx Nomadics holds the rights to. ==Technology== OneStep®6 is a propretary injection method featured on many models of Pioneer and all models of Pioneer FE. In this injection method, Taylor dispersion is exploited to generate analyte concentration gradient that provides a high-resolution dose response in a single injection for enhanced biophysical characterization and increased throughput. The technique provides a method for determination of the analyte diffusion coefficient and can be used to assess whether the analyte is heterogeneous or aggregated. The OneStep® injection was first described in 2012 by the name TDi but has since been renamed OneStep®. FastStep®7 is a proprietary in situ-dilution method featured on many models of Pioneer and all models of Pioneer FE. This injection method enables stepped analyte gradient injections to be performed where the concentration of sample steps up, or down, according to a predefined profile without reliance on dispersive mixing in a flow channel. It is a higher throughput alternative to multiple fixed concentration injections required by other methods. The analyte concentration is modulated en route to the flow cell on-the-fly. The dissociation of analyte can be accurately estimated from a single dissociation phase curve recorded after the step injection is complete. The sample throughput can be increased by >10-fold compared to conventional methods. OneStep® and FastStep® are referred to collectively by the company as dynamic injection SPR (diSPR®). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SensiQ」の詳細全文を読む スポンサード リンク
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