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Separase
Separase, also known as separin, is a cysteine protease responsible for triggering anaphase by hydrolysing cohesin, which is the protein responsible for binding sister chromatids during the early stage of anaphase.〔http://www.uniprot.org/uniprot/Q14674〕 In humans, separin is encoded by the ''ESPL1'' gene. == Discovery ==
In ''S. cerevisiae'', separase is encoded by the ''esp1'' gene. Esp1 was discovered by Kim Nasmyth and coworkers in 1998.
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