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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク SiDNA ： ウィキペディア英語版 SiDNA Signal interfering DNA (siDNA) is a class of short modified double stranded DNA molecules, 8-64 base pairs in length. siDNA molecules are capable of inhibiting DNA repair activities by interfering with multiple repair pathways. In general, these molecules act by mimicking DNA breaks and interfering with recognition and repair of DNA damage induced on chromosomes by irradiation or genotoxic products. ==Mechanism of action== The siDNA family, led by ''Dbait'' consists of 32 base pairs deoxyribonucleotide forming an intramolecular double helix, which mimicks DNA double-strand break lesions. Dbait binds to and hyperactivate DNA-PK, an enzyme involved in DNA breaks signaling and repair. DNA-PK hyperactivation induces pan-nuclear phosphorylation of histone H2AX among all the chromatine. H2AX phosphorylation is the signal, which allows double-strand break repair proteins (from NHEJ and Homologous recombination pathways) to form DNA repair complexes selectively on DNA double-strand breaks. Dbait-dependent unspecific phosphorylation of H2AX results in inefficient double strand break recognition and repair. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SiDNA」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.