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|Section2= |Section3= }} Slaframine is an indolizidine alkaloidal mycotoxin that generally causes salivation (slobbers) in most animals. It is usually produced by the fungus ''Rhizoctonia leguminicola''. It is a common fungal pathogen of red clover (''Trifolium pratense'') that causes black patch disease in the plant. Slaframine has the molecular formula C10H18N2O2.〔Smith G. W., (2007). Slaframine. In R.C.Gupta (Eds.), ''Veterinary Toxicology: Basic & Clinical Principles'', Chapter 81, pp. 1011-1013〕 The different environmental condition promotes the growth of the Rhizoctonia leguminicola fungus. For example, wet and humid weather are the favorable environmental condition for the growth of the fungus and production of slaframine. Legume hays contaminated with slaframine causes slobber syndrome and the various animals are sensitive to its effects.〔Gaskill C., (2010). Slaframine Toxication. ''Bluegrass Equine Digest''. Retrieved from http://www.ca.uky.edu/gluck/images/BED/BED-July10.pdf on April 12, 2011〕 ==History== In the late 1940s and 1950s in Midwestern United States, various agricultural experiment stations revealed the outbreaks of salivation in the cattle. In 1956, the first case of fungal contamination of red clover with Rhizoctonia leguminicola was reported which was mainly associated with a pasture disease called black patch. This was so called because it derives its name from the appearance of affected areas in the field. Most of these cases were associated with the feeding of second-cutting red clover hay.〔 Another serious outbreak of slobbers occurred in a herd of horses in the fall of 1979 near High Point, North Carolina. This was caused by a shipment of high-quality second-cutting red clover-orchard grass hay from a usual supplier in West Virginia.〔Hagler, W.M. & Behlow, R.F. (1981) (Salivary Syndrome in Horses: Identification of Slaframine in Red Clover Hay ), "Applied and Environmental Microbiology", 42 (6):1067-1073〕 In 2010, the slaframine toxin, or "slobber toxin" was also observed in Central Kentucky because of the wet spring weather and abundant clover growth.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Slaframine」の詳細全文を読む スポンサード リンク
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