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Spi-1 : ウィキペディア英語版
SPI1
__NOTOC__
Transcription factor PU.1 is a protein that in humans is encoded by the ''SPI1'' gene.
== Function ==

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6688 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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