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__NOTOC__ In molecular biology SprD (Small pathogenicity island RNA D) is a non-coding RNA expressed on pathogenicity islands in ''Staphylococcus aureus''. It was identified ''in silico'' along with a number of other sRNAs (SprA-G) through microarray analysis which were confirmed using a Northern blot. SprD has been found to significantly contribute to causing disease in an animal model.〔 ==Function== SprD is located between genes ''scn'' and ''chp'' in the innate immune evasion cluster (IEC) of the ''S. aureus'' genome. Its placement within this region was the first indication of a virulence-factor regulatory function.〔 SprD binds with ''sbi'' (''Staphylococcus aureus'' binder of IgG) mRNA which encodes an immune evasion protein. It occludes the Shine-Dalgarno sequence and the initiation codon of ''sbi'', forming a ''sbi'' mRNA-SprD duplex repressing the translation of the mRNA.〔 ''sbi'' protein interferes with the host's innate immune response by binding Factor H, Complement component 3 and IgG.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SprD」の詳細全文を読む スポンサード リンク
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