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Stiripentol
Stiripentol (marketed as Diacomit by Laboratoires Biocodex) is an anticonvulsant drug used in the treatment of epilepsy. It is approved for the treatment of Dravet syndrome, an epilepsy syndrome. It is unrelated to other anticonvulsants and belongs to the group of aromatic allylic alcohols.
==Mechanism of action==
As with most anticonvulsants, the precise mechanism is unknown. It has been shown to have anticonvulsant effects on its own.
It increases GABA transmission. At clinically relevant concentrations, STP enhances central GABA transmission through a barbiturate-like effect, since it increases the duration of opening of GABA-A receptors channels in hippocampal slices. It has also been shown that STP may increase the GABA levels in brain tissues and by interfering with its uptake and its metabolism. Specifically, it has been shown to inhibit lactate dehydrogenase, which is an important enzyme in the energy metabolism of neurons. Inhibition of this enzyme can make neurons less prone to fire action potentials, probably through activation of adenosine triphosphate sensitive potassium channels.
It also improves the effectiveness of many other anticonvulsants, possibly due to it inhibiting certain enzymes. This slows the drug's metabolism, increasing blood plasma levels.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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