翻訳と辞書 Words near each other ・ Supaksorn Nuntana ・ Supalai Park Towers ・ Supaman High ・ Supamo River ・ Supan River ・ Supanara Sukhasvasti ・ Supanat Chalermchaichareonkij ・ Supandi ・ Supanecan languages ・ Supanet Limited ・ Supangle ・ Supangmung ・ Supanova Pop Culture Expo ・ Supaphorn Prompinit ・ Supaplex ・ SuPAR ・ Suparawra ・ SUPARCO Satellite Ground Station ・ Supardi Nasir ・ Supardjo ・ Supare Akoko ・ SupaRed ・ Supari (film) ・ Suparibağ ・ Suparna ・ Suparna Anand ・ Suparna Marwah ・ Suparno Satpathy ・ Suparnostic ・ Suparshvanatha Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク SuPAR ： ウィキペディア英語版 SuPAR suPAR, soluble urokinase-type plasminogen activator receptor, (NCBI Accession no. AAK31795) is the soluble form of uPAR. uPAR is a membrane bound receptor for uPA, otherwise known as urokinase as well as Vitronectin. suPAR results from the cleavage and release of membrane-bound uPAR. suPAR concentration positively correlates to the activation level of the immune system and is present in plasma, urine, blood, serum, and cerebrospinal fluid. suPAR is a marker of disease severity and aggressiveness. 〔Thunø, Maria, Betina Macho, and Jesper Eugen-Olsen. "SuPAR: The Molecular Crystal Ball." Disease Markers 27 (2009): 157-72.〕 ==Molecular characteristics== suPAR has a secondary structure of 17 anti parallel β-sheets with 3 short α-helices. There are three homologous domains of suPAR: DI, DII, and DIII. In the comparison of cDNA sequences, DI differs from DII and DIII in its primary and tertiary structure, causing its distinct ligand binding properties.〔〔M. Huang, A. P. Mazar, G. Parry, A. A.-R. “Higazi, A. Kuo and D. B. Cines. Crystallization of soluble urokinase receptor (suPAR) in complex with urokinase amino-terminal fragment (1-143)”. Acta Crystallographica (2005): D61 (6), 697-700.〕 The GPI-anchor links uPAR to the cell membrane making it available for uPA binding. When uPA is bound to the receptor, there is cleavage between the GPI-anchor and DIII, forming suPAR. There are three different suPAR forms: suPARI-III, suPARII-III, and suPARI. Of these three forms suPARII-III is known to be a chemotactic agent for promoting the immune system.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「SuPAR」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.