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Sulfation
Sulfation, sulfurylation, or sometimes incorrectly descirbed as sulfonation, in biochemistry is the enzyme-catalyzed conjugation of a sulfo group (not a sulfate or sulfuryl group) to another molecule. This biotransformation involves a sulfotransferase enzyme catalyzing the transfer of a sulfo group from a donor cosubstrate, usually 3'-phosphoadenosine-5'-phosphosulfate (PAPS), to a substrate molecule's hydroxyl or amine. Sulfation is involved in a variety of biological processes, including detoxification, hormone regulation, molecular recognition, cell signaling, and viral entry into cells.〔 It is among the reactions in phase II drug metabolism, oftentimes effective in rendering a xenobiotic less active from a pharmacological and toxicological standpoint, but sometimes playing a role in the activation of xenobiotics (e.g. aromatic amines, methyl-substituted polycyclic aromatic hydrocarbons). Another example of biological sulfation is in the synthesis of sulfonated glycosaminoglycans, such as heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate. Sulfation is also a possible posttranslational modification of proteins.
==Tyrosine sulfation==
Tyrosine sulfation is a posttranslational modification in which a tyrosine residue of a protein is sulfated by a tyrosylprotein sulfotransferase (TPST) typically in the Golgi apparatus. Secreted proteins and extracellular parts of membrane proteins that pass through the Golgi apparatus may be sulfated. Such sulfation was first discovered by Bettelheim in bovine fibrinopeptide B in 1954〔Tyrosine-''O''-sulfate in a peptide from fibrinogen. F. R. Bettelheim, J. Am. Chem. Soc., 1954, 76 (10), pp 2838–2839, 〕 and later found be present in animals and plants but not in prokaryotes or in yeasts. Sulfation sites are tyrosine residues exposed on the surface of the protein typically surrounded by acidic residues. A detailed description of the characteristics of the sulfation site is available from PROSITE (PROSITE pattern: PS00003)(). Two types of tyrosylprotein sulfotransferases (TPST-1 and TPST-2) have been identified.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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