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"Super-enhancer" is a term used to describe the concept of large transcriptional enhancers. Large transcriptional enhancers have been studied since the 1990s. As currently defined, the term "super-enhancer" was introduced into the scientific literature in 2013. == Definition == Super-enhancers are most commonly defined using the program "ROSE" (Rank Ordering of Super-Enhancers). This links together regions of high-signal in ChIP-seq datasets using (1) a file specifying genome-wide signal and (2) a set of pre-defined enhancers. The transcription factors and histone marks used to define super-enhancers have been inconsistent between publications, however, H3K27ac and BRD4 are commonly used. The distance across which nearby enhancers can by linked is customizable, but is frequently chosen to be in the range of 10-20 kilobases. Many super-enhancer regions in current publications include transcription start sites and therefore do not meet most common definitions of enhancers. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Super-enhancer」の詳細全文を読む スポンサード リンク
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