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Words near each other
・ Swainson's flycatcher
・ Swainson's hawk
・ Swainson's sparrow
・ Swainson's spurfowl
・ Swainson's thrush
・ Swainson's warbler
・ Swainsona
・ Swainsona behriana
・ Swainsona formosa
・ Swainsona galegifolia
・ Swainsona greyana
・ Swainsona lessertiifolia
・ Swainsonia
・ Swainsonia fissurata
・ Swainsonia zephyra
Swainsonine
・ Swainsthorpe
・ Swainsthorpe railway station
・ Swainston Manor
・ Swainswick
・ Swainton, New Jersey
・ Swain–Lupton equation
・ Swajnie
・ Swak na Swak
・ Swakeleys House
・ Swakeleys School for Girls
・ Swakop River
・ Swakopmund
・ Swakopmund Airport
・ Swakopmund Constituency


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Swainsonine : ウィキペディア英語版
Swainsonine

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Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in locoweed (likely its primary toxin) it also is a significant cause of economic losses in livestock industries, particularly in North America.
==Pharmacology==
Swainsonine inhibits glycoside hydrolases, specifically N-linked glycosylation. Disruption of Golgi alpha-mannosidase II with swainsonine induces hybrid-type glycans. These glycans have a Man5GlcNAc2 core with processing on the 3-arm that resembles so-called complex-type glycans.
The pharmacological properties of this product have not been fully investigated.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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