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SWISS-MODEL is a structural bioinformatics web-server dedicated to homology modeling of protein 3D structures. Homology modeling is currently the most accurate method to generate reliable three-dimensional protein structure models and is routinely used in many practical applications. Homology (or comparative) modelling methods make use of experimental protein structures ("templates") to build models for evolutionary related proteins ("targets"). Today, SWISS-MODEL consists of three tightly integrated components: (1) The SWISS-MODEL pipeline - a suite of software tools and databases for automated protein structure modelling,〔 (2) The SWISS-MODEL Workspace - a web-based graphical user workbench,〔 (3) The SWISS-MODEL Repository - a continuously updated database of homology models for a set of model organism proteomes of high biomedical interest. ==The Pipeline== SWISS-MODEL pipeline comprises the four main steps that are involved in building a homology model of a given protein structure: # Identification of structural template(s). BLAST and HHblits are used to identify templates. The templates are stored in the SWISS-MODEL Template Library (SMTL), which is derived from PDB. # Alignment of target sequence and template structure(s). # Model building and energy minimization. SWISS-MODEL implements a rigid fragment assembly approach for modelling. # Assessment of the model's quality using QMEAN, a statistical potential of mean force. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Swiss-model」の詳細全文を読む スポンサード リンク
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