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Synexpression
Synexpression is a type of non-random eukaryotic gene organization. Genes in a synexpression group may not be physically linked, but they are involved in the same process and they are coordinately expressed. It is expected that genes that function in the same process be regulated coordinately. Synexpression groups in particular represent genes that are simultaneously up- or down-regulated, often because their gene products are required in stoichiometric amounts or are protein-complex subunits.〔Niehrs, C. and Pollet, Nicolas. Synexpression groups in eukaryotes. Nature 1999 December 2; 402: 483 - 487.〕 It is likely that these gene groups share common ''cis''- and ''trans''-acting control elements to achieve coordinate expression.
Synexpression groups are determined mainly by analysis of expression profiles compiled by the use of DNA microarrays.〔 The use of this technology helps researchers monitor changes in expression patterns for large numbers of genes in a given experiment. Analysis of DNA microarray expression profiles has led to the discovery of a number of genes that are tightly co-regulated.〔
==Identification==
The identification of synexpression groups has had an impact on the way some scientists view evolutionary change in higher eukaryotes.〔 Since groups of genes involved in the same biological process often share one or more common control elements, it has been suggested that the differential expression of these synexpression groups in different tissues of organisms can contribute to co-evolution tissues, organs, and appendages.〔 Today it is commonly believed that it is not primarily the gene products themselves that evolve, but that it is the control networks for groups of genes that contribute most to the evolution of higher eukaryotes.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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