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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク TBC1D4 ： ウィキペディア英語版 TBC1D4 TBC1 domain family member 4, previously known as AS160 (Akt substrate of 160 kDa) is a protein that in humans is encoded by the ''TBC1D4'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9882 )〕 The 160 kD protein product was first discovered in a screen for novel substrates of the serine-threonine kinase Akt, which phosphorylates TBC1D4 after insulin stimulation. Insulin stimulation of fat and muscle cells results in translocation of the glucose transporter GLUT4 to the plasma membrane, and this translocation process is dependent on phosphorylation of TBC1D4. The role of TBC1D4 in GLUT4 translocation is mediated by its GTPase activating domain and interactions with Rab proteins in vesicle formation, increasing GLUT4 translocation when its GTPase activity is inhibited by Akt phosphorylation. Specifically, this inhibition activates RAB2A, RAB8A, RAB10 and RAB14. TBC1D4 also contains a calmodulin-binding domain, and this domain mediates phosphorylation-independent glucose uptake in muscle cells. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「TBC1D4」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.