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TBRG4
Transforming growth factor beta regulator 4 (TGF-β), also known as cell cycle progression restoration protein 2 (CPR2) and FAST kinase domain-containing protein 4 (FASTKD4), is a protein that in humans is encoded by the ''TBRG4'' gene on chromosome 7.〔UniProt: 〕〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9238 )〕 This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress and cell cycle progression. TGF-β is involved in cell proliferation in hematopoiesis and multiple myeloma. == Structure ==
TGF-β shares structural characteristics of the FASTKD family, including an N-terminal mitochondrial targeting domain and three C-terminal domains: two FAST kinase-like domains (FAST_1 and FAST_2) and a RNA-binding domain (RAP). The mitochondrial targeting domain directs TGF-β to be imported into the mitochondria. Though the functions of the C-terminal domains are unknown, RAP possibly binds RNA during trans-splicing.〔 TGF-β also contains multiple putative leucine zipper domains.〔
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