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TBX4 T-box transcription factor Tbx4 is a transcription factor that belongs to T-box gene family that is involved in the regulation of embryonic developmental processes.〔(【引用サイトリンク】Homo sapiens (human) )">url=http://www.ncbi.nlm.nih.gov/gene/9496 )〕 The transcription factor is encoded by the TBX4 gene located on human chromosome 17.〔 Tbx4 is known mostly for its role in the development of the hindlimb, but it also plays a critical role in the formation of the umbilicus. Tbx4 has been shown to be expressed in the allantois, hindlimb, lung and proctodeum.〔 == Function ==
Expression of Tbx4 is required for hindlimb outgrowth and is activated by a combined "caudal" Hox code, expressing a specified positional code that includes Pitx1. Together with Tbx5, Tbx4 plays a role in patterning the soft tissues (muscles and tendons) of the musculoskeletal system.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「TBX4」の詳細全文を読む
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