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V-type proton ATPase 116 kDa subunit a isoform 3 is an enzyme that in humans is encoded by the ''TCIRG1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10312 )〕 == Function == Through alternate splicing, this gene encodes two protein isoforms with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The two isoforms are: * long isoform a, also named OC116 * short isoform b, also named TIRC7 (N-terminus truncated, lacks amino acid residues 1-216 of the long isoform) TIRC7 is expressed in T lymphocytes and is essential for normal T cell activation. This variant uses a transcription start site that is within exon 5 of variant 1 followed by an intron as part of its 5' UTR.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=nuccore&cmd=search&term=TIRC7 )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「TCIRG1」の詳細全文を読む スポンサード リンク
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