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・ TFAM
・ TFAP2A
・ TFAP2B
・ TFAP2C
・ TFAP2D
・ TFAP2E
・ TFAP4
・ TFB
・ TFB1M
・ TFB2M
・ TFBOYS
・ TFC
・ TFC Academy
・ TFCA
・ TFcon
TFCP2
・ TFCU
・ TFD
・ TFDC
・ TFDP1
・ TFDP2
・ TFE
・ TFE3
・ TFEB
・ TFEC
・ TFF
・ TFF First League
・ TFF Rudolstadt
・ TFF Second League
・ TFF Third League


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TFCP2 : ウィキペディア英語版
TFCP2

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the ''TFCP2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7024 )
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1. Late SV40 factor (LSF) also acts as an oncogene in hepatocellular carcinoma. Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).
Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.〔 The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.〔〔
==Interactions==
TFCP2 has been shown to interact with APBB1 and RNF2.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「TFCP2」の詳細全文を読む



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