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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク TIE-1 ： ウィキペディア英語版 TIE1 Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the ''TIE1'' gene. == Function == TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells and platelets.〔Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (Nov 2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". ''J Vasc Res. 2000 Nov-Dec;37(6):437-42. ''(PMID 11146396 )〕 TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「TIE1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.