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・ Tiemann
・ Tiemannite
・ Tieme Klompe
・ Tiemen Brouwer
・ Tiemen Groen
・ Tiemena
・ Tiemenguan
・ Tie Vapauteen
・ Tie Ya Na
・ Tie Ying
・ Tie Your Dream to Mine
・ Tie Your Mother Down
・ Tie-breaking in Swiss-system tournaments
・ Tie-dye
・ Tie-in
TIE1
・ Tieba Traoré
・ Tieback
・ Tieback (geotechnical)
・ Tiebaghi
・ Tiebas-Muruarte de Reta
・ Tiebata
・ Tiebout model
・ Tiebreak Theatre
・ Tiebreaker
・ Tiechang
・ Tieck
・ Tied & Tickled Trio
・ Tied & True
・ Tied aid


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TIE1 : ウィキペディア英語版
TIE1

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the ''TIE1'' gene.
== Function ==

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells and platelets.〔Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (Nov 2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". ''J Vasc Res. 2000 Nov-Dec;37(6):437-42. ''(PMID 11146396 )〕 TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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