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・ Tightwork 3000
・ Tighvein
・ Tighza
・ Tigi
・ Tigidius Perennis
・ Tigignas
・ Tigil River
・ Tigilau Ness
・ Tigilsky District
・ Tigin
・ Tigiria
・ Tigiria State
・ Tigisi
・ Tigist Shibabaw
・ Tigist Tufa
TIGIT
・ Tiglachin Monument
・ Tiglao
・ Tiglath-Pileser
・ Tiglath-Pileser I
・ Tiglath-Pileser II
・ Tiglath-Pileser III
・ Tiglath-Pileser IV
・ Tiglic acid
・ Tiglieto
・ Tiglieto Abbey
・ Tigliole
・ Tiglukpuk Formation
・ Tiglyl-CoA
・ Tigmamanukan


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TIGIT : ウィキペディア英語版
TIGIT

TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity.〔
Research has shown that TIGIT-Fc fusion protein could interact with PVR on dendritic cells and increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation in vivo.〔
TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain
==See also==

* T cell receptor
* Antigen

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「TIGIT」の詳細全文を読む



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