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Words near each other
・ Tirangsi
・ Tirani
・ Tirania
・ Tiraniemai
・ Tiranimia
・ Tiranny
・ Tirano
・ Tirano (Rhaetian Railway station)
・ Tirano railway station (RFI)
・ Tirano–Lecco railway
・ Tirant lo Blanc (film)
・ Tirant lo Blanch
・ Tirante
・ Tiranë (river)
・ Tiranë Heliport
TIRAP
・ Tirap
・ Tirap district
・ Tirap River
・ Tirapata District
・ Tirapazamine
・ Tirappuwa
・ Tirapu
・ Tiraque
・ Tiraque Municipality
・ Tiraque Province
・ Tirard
・ Tirari Desert
・ Tirari-Sturt Stony Desert
・ Tiras


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TIRAP : ウィキペディア英語版
TIRAP

TIRAP is an adapter molecule associated with toll-like receptors.
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
==See also==

* Myd88

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「TIRAP」の詳細全文を読む



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