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TMPRSS2
Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the ''TMPRSS2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7113 )〕
==ERG gene fusion== TMPRSS2 protein's function in prostate carcinogenesis relies on overexpression of ETS transcription factors, such as ''ERG'' and ''ETV1'', through gene fusion. TMPRSS2-ERG fusion gene is the most frequent, present in 40% - 80% of prostate cancers in humans. ERG overexpression contributes to development of androgen-independence in prostate cancer through disruption of androgen receptor signaling.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「TMPRSS2」の詳細全文を読む
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