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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク TNNC1 ： ウィキペディア英語版 Troponin C type 1 Troponin C, also known as TN-C or TnC, is a protein that resides in the troponin complex on actin thin filaments of striated muscle (cardiac, fast-twitch skeletal, or slow-twitch skeletal) and is responsible for binding calcium to activate muscle contraction. Troponin C is encoded by the ''TNNC1'' gene in humans〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7134 )〕 for both cardiac and slow skeletal muscle. == Structure == Cardiac troponin C (cTnC) is a 161-amino acid protein 〔(【引用サイトリンク】 Troponin C, slow skeletal and cardiac muscles )〕 organized into two domains: the regulatory N-terminal domain (cNTnC, residues 1-86), the structural C-terminal domain (cCTnC, residues 93-161), and a flexible linker connecting the two domains (residues 87-92). Each domain contains two EF-hands, Ca2+-binding helix-loop-helix motifs exemplified by proteins like parvalbumin. and calmodulin. In cCTnC the two EF-hand motifs constitute two high affinity Ca2+-binding sites. that are occupied at all physiologically relevant calcium concentrations. In contrast, only the second EF-hand in cNTnC binds Ca2+ with low affinity, while the first EF-hand Ca2+-binding site is defunct. In a typical EF-hand protein like calmodulin, Ca2+ binding induces a closed-to-open conformational transition, exposing a large hydrophobic patch in the open state. Likewise, the cardiac troponin regulatory domain, cNTnC, is in a closed conformation in the apo state (no calcium bound). Upon Ca2+ binding, cNTnC enters into a rapid equilibrium between closed and open forms, however, the closed form still predominates.〔 The structural domain, cCTnC, exists as a "molten globule" in the apo state, but forms a well structured open conformation in the Ca2+-bound state. These structural differences change the relative stabilities of the apo- and Ca2+-bound states, accounting for the divergent Ca2+-binding affinities between the two domains. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Troponin C type 1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.