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TNNI1
Troponin I, slow skeletal muscle is a protein that in humans is encoded by the ''TNNI1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7135 )〕 It is a tissue-specific subtype of troponin I, which in turn is a part of the troponin complex.
Gene ''TNNI1'', troponin I type 1 (skeletal muscle, slow), also known as ''TNN1'' and ''SSTNI'', is located at 1q31.3 in the human chromosomal genome, encoding the slow twitch skeletal muscle isoform of troponin I (ssTnI), the inhibitory subunit of the troponin complex in striated muscle myofilaments. Human ''TNNI1'' spans 12.5 kilobases in the genomic DNA and contains 9 exons and 8 introns. Exon 2 to exon 8 contain the coding sequences, encoding a protein of 21.7 kDa consisting of 187 amino acids including the first methionine with an isoelectric point (pI) of 9.59.
== Gene evolution ==
Three homologous genes have evolved in vertebrates, encoding three muscle type-specific isoforms of TnI.〔 In mammals, the amino acid sequence of ssTnI is highly conserved. Mouse and bovine ssTnI each differs from human ssTnI in only four amino acids, and rhesus monkey ssTnI is identical to human in the amino acid sequences. In lower vertebrates, the divergence of ssTnI between species is larger than that in the higher vertebrates (Fig1).
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