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TONSL
Tonsoku-like, DNA repair protein is a protein that in humans is encoded by the TONSL gene. 〔 (【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/gene/4796 )〕 ==Function==
The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. (by RefSeq, Jul 2008 ). ##Evidence-Data-START## Transcript exon combination :: BC008782.2 () RNAseq introns :: mixed/partial sample support ERS025081, ERS025082 () ##Evidence-Data-END##
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「TONSL」の詳細全文を読む
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