翻訳と辞書 Words near each other ・ TP ・ TP (Teddy Pendergrass album) ・ TP (Tony Parker album) ・ TP 52 ・ TP de Oro ・ TP Formula ・ TP Mazembe ・ TP model transformation in control theory ・ TP Molunge ・ TP Properties ・ TP Stratten ・ TP Sudhindra ・ TP USCA Bangui ・ TP Vision ・ TP-003 ・ TP-13 ・ TP-2.com ・ TP-47 ・ TP-70 ・ TP-82 ・ TP-Link ・ TP-Seinäjoki ・ TP.3 Reloaded ・ TP53-inducible glycolysis and apoptosis regulator ・ TP53BP1 ・ TP53BP2 ・ TP53I11 ・ TP53I3 ・ TP53INP1 ・ TP53RK Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク TP-13 ： ウィキペディア英語版 TP-13 TP-13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype-selective partial agonist at GABAA receptors, binding selectively to GABAA receptor complexes bearing α2 and α3 subunits.〔McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. ''Neuropharmacology''. 2004 Feb;46(2):171-8. PMID 14680756〕 It has modest anticonvulsant activity although less than that of diazepam,〔Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. ''Journal of Psychopharmacology''. 2007 Jun;21(4):384-91. PMID 17092983〕 and its main effect is likely to be selective anxiolytic action, as seen with other related α2/3-preferring agonists such as L-838,417. == References == 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「TP-13」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.