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Transient receptor potential channels (TRP channels) are a large group of ion channels, comprising six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi. TRP channels were initially discovered in the ''trp'' mutant strain of the fruit fly ''Drosophila'' which displayed transient elevation of potential in response to light stimuli and were so named "transient receptor potential" channels. The name now refers only to a family of proteins with similar structure and function, not to the mechanism of their activation. Later, TRP channels were found in vertebrates where they are ubiquitously expressed in many cell types and tissues. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: group 1 includes, TRPC ( "C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN and TRPA. In group 2 there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). TRPC, ion channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium, but all TRPVs, TRPM3, TRPM6 and TRPM7 are highly calcium selective. == Sub-families == They are encoded by at least 100 channel subunit genes divided into seven sub-families: * TRPC (canonical) - associated with Focal segmental glomerulosclerosis * TRPV (vanilloid)- sensitive to capsaicin * TRPA (ankyrin)- sensitive to stress * TRPM (melastatin) -- associated with Hypomagnesemia with secondary hypocalcemia * TRPP (polycystin) -- associated with Polycystic kidney disease, can lead to polycystic kidney disease * TRPML (mucolipin) -- associated with Mucolipidosis type IV, protein leak channels * TRPN (NOMPC) - no mechanoreceptor potential C - not found in mammals 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「TRPV」の詳細全文を読む スポンサード リンク
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