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・ Talamasca (group)
・ Talamasca Caste
・ Talamaur
・ Talamba Dam
・ Talambeh Khaneh Pol Baba Hoseyn
・ Talambeh Khaneh Razan
・ Talambote
・ Talambrun Ali Shir
・ Talambu
・ Talamello
・ Talamidaw
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・ Talampaya National Park
Talampicillin
・ Talamporuwa
・ Talamri
・ Talamtam
・ Talan Skeels-Piggins
・ Talan Teidit
・ Talana
・ Talana, KwaZulu-Natal
・ Talanayar block
・ Talance Sawyer
・ Talandasht
・ Talang
・ Talang 2007
・ Talang 2008
・ Talang 2009


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Talampicillin : ウィキペディア英語版
Talampicillin

Talampicillin is a beta lactam antibiotic from the penicillin family. It is an acid stable prodrug that was administered orally. It is not approved by the FDA for use in the United States.
==Synthesis==
Ampicillin remains the penicillin of choice for many infections because of its oral activity and good potency against Gram-negative bacteria. A number of prodrugs have been examined in attempts to improve upon the pharmacodynamic characteristics, and one of these is talampicillin.
One synthesis involved protecting the primary amino group of ampicillin (1) as the enamine with ethyl acetoacetate (2). THis was then esterified by reaction with 3-bromopthalide (3), and the enamine was carefully hydrolyzed with dilute HCl in acetonitrile to produce talampicillin (4).

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