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Telokin (also known as kinase-related protein or KRP) is an abundant protein found in smooth-muscle. It is identical to the C-terminus of myosin light-chain kinase. Telokin may play a role in the stabilization of unphosphorylated smooth-muscle myosin filaments. Because of its origin as the C-terminal end of smooth muscle myosin light chain kinase, it is called "telokin" (from a combination of the Greek telos, "end" and kinase). == Nomenclature and classification == Telokin's systematic name is ATP:(light chain ) O-phosphotransferase and its recommended name is myosin-light-chain. (). The gene ''MYLK'', a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. The two transcrips that produce the two telokin isoforms are the following: ; Isoform 7: This variant encodes the shorter isoform of kinase related protein, telokin. The first exon corresponds to intron 30 and there mainder of the transcript corresponds to the last two exons of the gene. It is shorter than variant 8 by one codon at the splicing junction between the first two exons. It is made by 153 aa. NCBI Reference Sequence: (NP_444259.1. ) It comes from the Homo sapiens myosin light chain kinase (MYLK), transcript variant 7, mRNA, whose length is 2676 bp. NCBI Reference Sequence: (NM_053031.2. ) ; Isoform 8: This variant encodes the longer isoform of kinase related protein, telokin. It is longer than variant 7 by one codon at the splicing junction between the first two exons. It is composed of 154 aa. NCBI Reference Sequence: (NP_444260.1. ) It comes from the Homo sapiens myosin light chain kinase (MYLK), transcript variant 8, mRNA, whose length is 2679 bp. NCBI Reference Sequence: (NM_053032.2. ) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Telokin」の詳細全文を読む スポンサード リンク
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