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Tenidap
Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis,〔Staff, American Journal of Nursing. ( Drug Watch: Tenidap Offers Arthritis Therapy Minus Toxicity ) AJN 1996 96(1):58〕 but Pfizer halted development after marketing approval was rejected by the FDA in 1996〔Pfizer. Sept 27, 1996 (Press release: Pfizer To Halt Plans For Commercialization Of Tenidap For Rheumatoid Arthritis )〕 due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.〔Hwang SH et al. Rationally designed multitarget agents against inflammation and pain. Curr Med Chem. 2013;20(13):1783-99. PMID 23410172 (PMC 4113248 )〕 ==References==
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