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Teprotide : ウィキペディア英語版
Teprotide

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Teprotide is nonapeptide which has been isolated from the snake ''Bothrops jararaca''. It is an angiotensin converting enzyme inhibitor (ACE inhibitor), which inhibits the conversion of angiotensin I to angiotensin II and may potentiate some of the pharmacological actions of bradykinin. It has a molecular formula of C53H76N14O12 and has been looked at as an antihypertension agent.
==Isolation and Synthesis==

The antihypertensive effects of teprotide were first observed by Sergio Ferreira in 1965 and it was first isolated by Ferreira ''et al.'' along with eight other peptides in 1970. Teprotide was synthesized in 1970 by Ondetti ''et al.'' and from there its antihypertensive properties were studied more closely.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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