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|Section2= |Section3= }} Tetrandrine a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a "Quinidine like" anti-arrhythmic effect. It has been isolated from ''Stephania tetrandra'' S Moore,〔Zhang L, Geng Y, Duan W, Wang D, Fu M, Wang X.,"Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae. ''J Sep Sci.'' 2009 Oct;32(20):3550-4〕 and other Chinese and Japanese herbs. It has vasodilatory properties and can therefore reduce blood pressure.〔Kwan CY, Achike FI.,"Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action." ''Acta Pharmacol Sin.'' 2002 Dec;23(12):1057-68.〕 Tetrandrine may have potential use for the treatment of liver disease〔Feng D, Mei Y, Wang Y, Zhang B, Wang C, Xu L.,"Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-kappaB activation." '' Immunol Lett.'' 2008 Dec 22;121(2):127-33〕 and liver cancer.〔Liu C, Gong K, Mao X, Li W.,"Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma." Int J Cancer. 2011 Sep 15;129(6):1519-31〕〔Cheng Z, Wang K, Wei J, Lu X, Liu B"Proteomic analysis of anti-tumor effects by tetrandrine treatment in HepG2 cells." ''Phytomedicine''. 2010 Nov;17(13):1000-5〕〔Zhong Yao Cai. .,"(study of anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402 )" 2008 Oct;31(10):1522-5 Authors: Deng WY, Luo SX, Zhou MQ, Li N, Chen XB, Han LL〕 Tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation.〔Kitano A, Yamanaka O, Ikeda K, Ishida-Nishikawa I, Okada Y, Shirai K, Saika S"Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro." ''Curr Eye Res''. 2008 Jul;33(7):559-65〕 Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis.〔Kwan CY, Achike FI.,"Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action." ''Acta Pharmacol Sin''. 2002 Dec;23(12):1057-68.〕 Tetrandrine has also been shown to inhibit entry of Ebola virus into host cells ''in vitro'' and showed therapeutic efficacy against Ebola in preliminary studies on mice.〔Sakurai Y, et al. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. ''Science'' 2015;347(6225):995-998. DOI 10.1126/science.1258758〕 ==Biosynthesis== Tetrandrine is biosynthesized from a free radical coupled dimerization of ''S''-''N''-methylcoclaurine:〔Dewan S. Bhakuni, Sudha Jain, Awadhesh N. Singh. "Biosynthesis of the bisbenzylisoquinoline alkaloid, tetrandrine" ''Phytochemistry'' (1980); 19(11):2347–2350〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tetrandrine」の詳細全文を読む スポンサード リンク
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