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Tetrazepam
Tetrazepam〔NL Patent 6600095〕 (is marketed under the following brand names, Clinoxan, Epsipam, Myolastan, Musaril, Relaxam and Spasmorelax) is a benzodiazepine derivative with anticonvulsant, anxiolytic, hypnotic and muscle relaxant properties. It was formerly used mainly in Austria, France, Belgium, Germany and Spain to treat muscle spasm, anxiety disorders such as panic attacks, or more rarely to treat depression, premenstrual syndrome or agoraphobia. Tetrazepam has relatively little sedative effect at low doses while still producing useful muscle relaxation and anxiety relief. The Co-ordination Group for Mutual Recognition and Decentralised Procedures-Human (CMD(h)) endorsed the Pharmacovigilance Risk Assessment Committee (PRAC) recommendation to suspend the marketing authorisations of tetrazepam-containing medicines across the European Union (EU) in April 2013.〔(Recommendation to suspend tetrazepam-containing medicines endorsed by CMDh ), European Medicines Agency, published 29 April 2013〕 The European Commission has confirmed the suspension of the marketing authorisations for Tetrazepam in Europe because of cutaneous toxicity, effective from the 1 August 2013.〔(Ruhen der Zuhlassung aller Tetrazepam-haltiger Arzneimittel ), ''Sanofi-Avensis Deutschland GmbH'' (German), published June 2013〕
Delayed type 4 allergic hypersensitivity reactions including aculopapular exanthema, erythematous rash, urticarial eruption, erythema multiforme, photodermatitis, eczema and Stevens–Johnson syndrome can occasionally occur as a result of tetrazepam exposure. These hypersensitivity reactions to tetrazepam share no cross-reactivity with other benzodiazepines.
==Indications==
Tetrazepam is used therapeutically as a muscle relaxant.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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