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TheraSphere
TheraSphere is a hepatocellular carcinoma (HCC) treatment therapy that consists of millions of microscopic, radioactive glass microspheres (20–30 micrometres in diameter) being infused into the arteries that feed liver tumors. These microspheres then embolize, lodging themselves in the liver's capillaries and bathing the malignancy in high levels of yttrium-90 radiation. It is currently approved for patients as a neoadjuvant to surgery or transplantation by the U.S. Food and Drug Administration and is being used at a number of clinical centers in the United States.
==Description==
TheraSphere consists of insoluble glass microspheres where yttrium-90 is an integral constituent of the glass. Each milligram contains between 22,000 and 73,000 microspheres. Yttrium-90 is a pure beta emitter (physical half-life of 64.2 hours or 2.67 days) and decays to stable zirconium-90. The average energy of the beta emissions from yttrium-90 is 0.9367 MeV.
Following embolization of the yttrium-90 glass microspheres in tumorous liver tissue, the beta radiation emitted provides a therapeutic effect. The microspheres are delivered into the liver tumor through a catheter placed into the hepatic artery that supplies blood to the tumor (This is usually performed in a hospital's radiology suite and patients remain conscious throughout the procedure). The microspheres are unable to pass through the vasculature of the liver due to arteriolar capillary blockade and are trapped in the tumor. There they exert a local radiotherapeutic effect with some damage to surrounding normal liver tissue.〔http://www.nordion.com/therasphere/physicians-package-insert/package-insert-us.pdf〕〔(TheraSphere - Innovative Form of Radiation Therapy for Inoperable Liver Cancer )〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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